Structural diversity in a human antibody germline library
نویسندگان
چکیده
منابع مشابه
Structural diversity in a human antibody germline library
To support antibody therapeutic development, the crystal structures of a set of 16 germline variants composed of 4 different kappa light chains paired with 4 different heavy chains have been determined. All four heavy chains of the antigen-binding fragments (Fabs) have the same complementarity-determining region (CDR) H3 that was reported in an earlier Fab structure. The structure analyses incl...
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ژورنال
عنوان ژورنال: mAbs
سال: 2016
ISSN: 1942-0862,1942-0870
DOI: 10.1080/19420862.2016.1190060